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Article

EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis

17 Dec 2021

Abstract excerpt

Abstract The erythroid terminal differentiation program couples sequential cell divisions with progressive reductions in cell size. The erythropoietin receptor (EpoR) is essential for erythroblast survival, but its other functions are not well characterized. Here we use Epor −/− mouse erythroblasts endowed with survival signaling to identify novel non-redundant EpoR functions. We find that, paradoxically, EpoR...

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Share to Erythrocyte Function and Pathophysiology
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PMID: 34921133
DOI: 10.1038/s41467-021-27562-4

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