Article
Structural insight into the zinc finger CW domain as a histone modification reader.
Structure (London, England : 1993) - 8 Sept 2010
He Fahu, Umehara Takashi, Saito Kohei, Harada Takushi, Watanabe Satoru, Yabuki Takashi, Kigawa Takanori, Takahashi Mari, Kuwasako Kanako, Tsuda Kengo, Matsuda Takayoshi, Aoki Masaaki, Seki Eiko, Kobayashi Naohiro, Güntert Peter, Yokoyama Shigeyuki, Muto Yutaka
Abstract excerpt
The zinc finger CW (zf-CW) domain is a motif of about 60 residues that is frequently found in proteins involved in epigenetic regulation. Here, we determined the NMR solution structure of the zf-CW domain of the human zf-CW and PWWP domain containing protein 1 (ZCWPW1). The zf-CW domain adopts a new fold in which a zinc ion is coordinated tetrahedrally by four conserved Cys ligand residues. The tertiary structure...
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