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Article

Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.

Nature structural & molecular biology - 1 Dec 2005

Wu Wei-Hua, Alami Samar, Luk Edward, Wu Chwen-Huey, Sen Subhojit, Mizuguchi Gaku, Wei Debbie, Wu Carl

Abstract excerpt

The histone variant H2AZ is incorporated preferentially at specific locations in chromatin to modulate chromosome functions. In Saccharomyces cerevisiae, deposition of histone H2AZ is mediated by the multiprotein SWR1 complex, which catalyzes ATP-dependent exchange of nucleosomal histone H2A for H2AZ. Here, we define interactions between SWR1 components and H2AZ, revealing a link between the ATPase domain of Swr1...

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PMID: 16299513
DOI: 10.1038/nsmb1023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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