Article

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

2023-07-03

Abstract excerpt

<h4>SUMMARY</h4> Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). Here, we identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility in the aging brain. βHB is a small molecule metabolite which primarily provides an oxidative substrate for ATP during hypoglycemic conditions, and also regulates other cellular processes through covalent and noncovalent protein inte...

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Literature Corpus work: c5e52a72-9819-5b9c-be1a-a0e272a3ee17
DOI: 10.1101/2023.07.03.547547

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