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Function and mechanism of histone β-hydroxybutyrylation in health and disease

12 Sept 2022

Abstract excerpt

Histone post-translational modifications (HPTMs) are essential epigenetic mechanisms that affect chromatin-associated nuclear processes without altering the DNA sequence. With the application of mass spectrometry-based proteomics, novel histone lysine acylation, such as propionylation, butyrylation, crotonylation, malonylation, succinylation, glutarylation, and lactoylation have been successively discovered. The...

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PMID: 36172354
DOI: 10.3389/fimmu.2022.981285

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