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Novel histone post-translational modifications in Alzheimer’s disease: current advances and implications

9 Mar 2024

Abstract excerpt

Alzheimer's disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially acetylation, play a significant role in it. With the development of mass spectrometry and proteomics, an increasing number of novel HPTMs, including lactoylation, crotonylation, β-hydroxybutyrylation, 2-hydroxyisobutyrylation, succinylation, and malonylation, have been...

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PMID: 38461320
DOI: 10.1186/s13148-024-01650-w

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