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Article

Label-free single-cell RNA multiplexing leveraging genetic variability.

Nature communications - 5 Dec 2024

Hoeft Konrad, Bleckwehl Tore, Schumacher David, Kim Hyojin, Meyer Robert, Long Qingqing, Zhang Ling, Möller Christian, Clahsen-van Groningen Marian C, Babler Anne, Saritas Turgay, Kurth Ingo, Milting Hendrik, Hayat Sikander, Kramann Rafael

Abstract excerpt

Single cell RNA sequencing has provided unprecedented insights into the molecular cues and cellular heterogeneity underlying human disease. However, the high costs and complexity of single cell methods remain a major obstacle for generating large-scale human cohorts. Here, we compare current state-of-the-art single cell multiplexing technologies, and provide a widely applicable demultiplexing method, SoupLadle,...

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Identifiers

PMID: 39638798
DOI: 10.1038/s41467-024-54270-6
PMCID: PMC11621319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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