Article

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths

2022-06-09

Abstract excerpt

<h4>ABSTRACT</h4> RNA splicing factors are recurrently affected by alteration-of-function mutations in clonal blood disorders, highlighting the importance of splicing regulation in hematopoiesis. However, our understanding of the impact of dysregulated RNA splicing has been hampered by the inability to distinguish mutant and wildtype cells in primary patient samples, the cell-type complexity of the hematopoietic...

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Literature Corpus work: e2005aaa-bc80-5da2-a36e-454e45b51ef6
DOI: 10.1101/2022.06.08.495292

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