Article

Uncovering the molecular basis of kinase activity and substrate recognition with phospho-PCA

2025-11-07

Abstract excerpt

<h4>SUMMARY</h4> Protein kinases relay information to various cellular processes, and their dysregulation underlies numerous human diseases. Despite their importance, our understanding of how kinase domains and their variants impact protein stability, catalytic activity, and substrate recognition is incomplete. In this work, we develop the phosphorylation protein complementation assay (phospho-PCA), which enables...

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Literature Corpus work: c5dea1f6-2321-5ab0-83ae-4261a007fab9
DOI: 10.1101/2025.11.07.687244

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