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Accurate, high-coverage assignment of <i>in vivo</i> protein kinases to phosphosites from <i>in vitro</i> phosphoproteomic specificity data

2021-09-01

Abstract excerpt

Phosphoproteomic experiments routinely observe thousands of phosphorylation sites. To understand the intracellular signaling processes that generated this data, one or more causal protein kinases must be assigned to each phosphosite. However, limited knowledge of kinase specificity typically restricts assignments to a small subset of a kinome. Starting from a statistical model of a high-throughput, in vitro kinas...

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Literature Corpus work
89359a8f-f53e-5421-9d7a-07cf867c246f
DOI
10.1101/2021.08.31.458376
Open publication

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Accurate, high-coverage assignment of <i>in vivo</i> protein kinases to phosphosites from <i>in vitro</i> phosphoproteomic specificity dataDOI 10.1101/2021.08.31.458376
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