Article

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein-protein interactions

2021-11-19

Abstract excerpt

Protein kinases play an important role in cellular signaling pathways and their dysregulation leads to multiple diseases, making kinases prime drug targets. While more than 500 human protein kinases are known to collectively mediate phosphorylation of over 290,000 S/T/Y sites, the activities have been characterized only for a minor, intensively studied subset. To systematically address this discrepancy, we develop...

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Identifiers and source

Literature Corpus work: 1c8c1965-adfe-5634-b1f6-fef365c2cd4c
DOI: 10.1101/2021.11.18.469002

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