Accurate prediction of deleterious protein kinase polymorphisms.

Abstract excerpt

MOTIVATION: Contemporary, high-throughput sequencing efforts have identified a rich source of naturally occurring single nucleotide polymorphisms (SNPs), a subset of which occur in the coding region of genes and result in a change in the encoded amino acid sequence (non-synonymous coding SNPs or 'nsSNPs'). It is hypothesized that a subset of these nsSNPs may underlie common human disease. Testing all these...

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• Base Sequence
• Chromosome Mapping
• DNA Mutational Analysis
• Molecular Sequence Data
• Protein Kinases