Article

CoPhosK: A Method for Comprehensive Kinase Substrate Annotation Using Co-phosphorylation Analysis

2018-03-04

Abstract excerpt

We present CoPhosK to predict kinase-substrate associations for phosphopeptide substrates detected by mass spectrometry (MS). The tool utilizes a Naïve Bayes framework with priors of known kinase-substrate associations (KSAs) to generate its predictions. Through the mining of MS data for the collective dynamic signatures of the kinases’ substrates revealed by correlation analysis of phosphopeptide intensity data,...

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Literature Corpus work: 342a930c-4327-5a28-a19b-65ab9cbadede
DOI: 10.1101/251009

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