Article

ETV4 restrains the formation of CD74 <sup>+</sup> cytotoxic exhausted CD8 <sup>+</sup> T cells

2025-10-04

Abstract excerpt

Exhausted CD8 + T (Tex) cells comprise heterogeneous subsets with varying cytotoxic and dysfunctional properties, making inhibitory receptor profiles unreliable indicators of function. Therefore, it is essential to define transcriptional regulators or markers that accurately reflect these states. Here, we identified ETS variant 4 (ETV4) as a transcription factor that restricts cytotoxic Tex differentiation within...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5dc4949-dbdb-5987-91c9-7b41053e185e
DOI: 10.1101/2025.10.02.677509

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ETV4 restrains the formation of CD74 <sup>+</sup> cytotoxic exhausted CD8 <sup>+</sup> T cellsDOI 10.1101/2025.10.02.677509Read

CD39 <sup>+</sup> conventional CD4 <sup>+</sup> T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockadeSemantic proximity Read

CD8 T Cell Exhaustion During Chronic Viral Infection and CancerSemantic proximity Read

CXCR4 orchestrates the TOX-programmed exhausted phenotype of CD8+ T cells via JAK2/STAT3 pathway.Semantic proximity Read

High-avidity TCR signaling induces a distinct KLR-positive exhaustion state in human tumor-infiltrating CD8 T cells associated with immunotherapy responseSemantic proximity Read

Phenotypic shifts of tumor associated macrophages and STAT3 mediated suppression of myeloid derived suppressor cells drive sensitization of HER2 <sup>+</sup> tumor immunitySemantic proximity Read

Bystander CD4 <sup>+</sup> T cells infiltrate human tumors and are phenotypically distinctSemantic proximity Read

Oncogenic role and drug sensitivity of ETV4 in human tumors: a pan-cancer analysisSemantic proximity Read

IRF4 instructs effector Treg differentiation and immune suppression in human cancerSemantic proximity Read

Transcriptomic landscape of CD8+ and CD4 + T-LGL leukemia revealed the distinct impact of STAT3 and STAT5B activating mutations.Semantic proximity Read

Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironmentSemantic proximity Read

Single-cell RNA sequencing of human double-negative T cells reveals a favorable cellular signature for cancer therapySemantic proximity Read

EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environmentSemantic proximity Read