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Article

IRF4 instructs effector Treg differentiation and immune suppression in human cancer

10 Mar 2020

Abstract excerpt

The molecular mechanisms responsible for the high immunosuppressive capacity of CD4+ Tregs in tumors are not well known. High-dimensional single-cell profiling of T cells from chemotherapy-naive individuals with non-small-cell lung cancer identified the transcription factor IRF4 as specifically expressed by a subset of intratumoral CD4+ effector Tregs with superior suppressive activity. In contrast to the IRF4-...

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PMID: 32125291
DOI: 10.1172/jci130426

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