Article

CD39 <sup>+</sup> conventional CD4 <sup>+</sup> T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

2023-02-01

Abstract excerpt

<h4>Background</h4> Conventional CD4 + T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to tumor elimination remains poorly understood. <h4>Methods</h4> Here we describe a subset of Tconv cells characterized by the expression of CD39. The phenotype, the effector function and transcriptional profile of tumor-infiltrating CD39 + Tconv lymphocytes from different mouse can...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbf60503-0413-5f0b-896a-18808ce1c199
DOI: 10.1101/2023.01.30.526262

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CD39 <sup>+</sup> conventional CD4 <sup>+</sup> T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockadeDOI 10.1101/2023.01.30.526262Read

Bystander CD4 <sup>+</sup> T cells infiltrate human tumors and are phenotypically distinctSemantic proximity Read

CD39 + tissue-resident memory CD8 + T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancerSemantic proximity Read

CD39 Identifies the CD4+ Tumor-Specific T-cell Population in Human CancerSemantic proximity Read

CD39 Identifies Tumor-Reactive CD8 T cells in Patients With Lung CancerSemantic proximity Read

Bystander CD4 + T cells infiltrate human tumors and are phenotypically distinctSemantic proximity Read

Human effector CD8 <sup>+</sup> T cells with an exhausted-like phenotype control tumor growth <i>in vivo</i> in a humanized tumor modelSemantic proximity Read

Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39Semantic proximity Read

Memory-promoting function of miR-379-5p attenuates CD8+ T cell exhaustion by targeting immune checkpointsSemantic proximity Read

Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunctionSemantic proximity Read

Genetically driven CD39 expression shapes human tumor-infiltrating CD8+ T-cell functions.Semantic proximity Read

CD39 is expressed on functional effector and tissue resident memory CD8+ T cellsSemantic proximity Read

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells.Semantic proximity Read