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Article

Transcriptomic landscape of CD8+ and CD4 + T-LGL leukemia revealed the distinct impact of STAT3 and STAT5B activating mutations.

Leukemia - 1 Oct 2025

Calabretto Giulia, Binatti Andrea, Teramo Antonella, Buratin Alessia, Barilà Gregorio, Gasparini Vanessa Rebecca, Vicenzetto Cristina, Gaffo Enrico, Rampazzo Elisa, Orsi Silvia, Buson Elena, Trimarco Valentina, Mariotti Barbara, Facco Monica, Bazzoni Flavia, Trentin Livio, Semenzato Gianpietro, Zambello Renato, Bortoluzzi Stefania

Abstract excerpt

The biological basis of the high clinical heterogeneity of T-LGL Leukemia (T-LGLL) is not completely understood and effective therapies for this disease are lacking. Through RNA-Sequencing of purified T-LGLs we reveal gene expression profiles and pathway dysregulations in the major patient subgroups, defined by CD8+ or CD4+ phenotype and STAT3/STAT5B mutational status. Overall, T-LGLL patients exhibited a marked...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40721648
DOI: 10.1038/s41375-025-02708-1
PMCID: PMC12463674

Genes

STAT3
STAT5B
CD4
MDM2
PIM1
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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