Article

Bystander CD4 <sup>+</sup> T cells infiltrate human tumors and are phenotypically distinct

2020-07-16

Abstract excerpt

Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8 + tumor-infiltrating lymphocytes (TILs). Here we study CD4 + TILs in human lung and colorectal cancers and observe that non-Treg CD4 + TILs average more than 70% of total CD4 + TILs in both cancer types. Leveraging high dimensional analyses including mass cytometry and single-cel...

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Literature Corpus work: 28770609-6a50-50aa-8342-d816de3fca05
DOI: 10.1101/2020.07.15.204172

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