Article

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock‐in (Hupki) mouse model

2010-05-18

Abstract excerpt

TP53 is one of the most commonly mutated genes in human tumours. Variations in the types and frequencies of mutations at different tumour sites suggest that they may provide clues to the identity of the causative mutagenic agent. A useful model for studying human TP53 mutagenesis is the partial human TP53 knock‐in (Hupki) mouse containing exons 4–9 of human TP53 in place of the corresponding mouse exons. For an in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5dc039f-95dd-524a-a7e1-e4c0489df748
DOI: 10.1111/j.1742-4658.2010.07676.x

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock‐in (Hupki) mouse modelDOI 10.1111/j.1742-4658.2010.07676.xRead

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse modelSemantic proximity Read

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.Semantic proximity Read

Mutagenicity of N-hydroxy-4-aminobiphenyl in human TP53 knock-in (Hupki) mouse embryo fibroblasts.Semantic proximity Read

p53 Mutations in Benzo(a)Pyrene-Exposed Human p53 Knock-in Murine Fibroblasts Correlate with p53 Mutations in Human Lung TumorsSemantic proximity Read

The genome as a record of environmental exposure.Semantic proximity Read

Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53.Semantic proximity Read

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of miceSemantic proximity Read

MEF immortalization to investigate the ins and outs of mutagenesis.Semantic proximity Read

TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation databaseSemantic proximity Read

p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer.Semantic proximity Read

Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice.Semantic proximity Read

Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid.Semantic proximity Read