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Article

Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice.

International journal of cancer - 15 Aug 2006

Tong Wei-Min, Lee Ming-Kei, Galendo Dominique, Wang Zhao-Qi, Sabapathy Kanaga

Abstract excerpt

Hepatocellular carcinoma (HCC) is a common human malignancy that is often associated with risk factors such as aflatoxin-B1 (AFB1) exposure and Hepatitis-B virus infection in developing countries. There is a strong correlation between these risk factors and mutation of the tumor-suppressor gene p53 at codon 249. In vitro experiments have also shown that treatment of human liver cells with AFB1 results in p53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16557586
DOI: 10.1002/ijc.21890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice.PMID 16557586Read ↗

Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53.Semantic proximity Read ↗

Aflatoxin B1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation within the p53 gene.Semantic proximity Read ↗

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse modelSemantic proximity Read ↗

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock‐in (Hupki) mouse modelSemantic proximity Read ↗

p53 Mutations in Benzo(a)Pyrene-Exposed Human p53 Knock-in Murine Fibroblasts Correlate with p53 Mutations in Human Lung TumorsSemantic proximity Read ↗

The human p53 gene mutated at position 249 per se is not sufficient to immortalize human liver cells.Semantic proximity Read ↗

The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice.Semantic proximity Read ↗

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.Semantic proximity Read ↗

Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene.Semantic proximity Read ↗

Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice.Semantic proximity Read ↗

Mutations associated with in vivo aflatoxin B1-induced carcinogenesis need not be present in the in vitro transformations by this toxin.Semantic proximity Read ↗

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines.Semantic proximity Read ↗

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