Mutagenicity of N-hydroxy-4-aminobiphenyl in human TP53 knock-in (Hupki) mouse embryo fibroblasts.

doi:10.1002/em.22429

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Article

Mutagenicity of N-hydroxy-4-aminobiphenyl in human TP53 knock-in (Hupki) mouse embryo fibroblasts.

Environmental and molecular mutagenesis - 1 Apr 2021

Hölzl-Armstrong Lisa, Kucab Jill E, Zwart Edwin P, Luijten Mirjam, Phillips David H, Arlt Volker M

Abstract excerpt

TP53 harbors somatic mutations in more than half of human tumors with some showing characteristic mutation spectra that have been linked to environmental exposures. In bladder cancer, a unique distribution of mutations amongst several codons of TP53 has been hypothesized to be caused by environmental carcinogens including 4-aminobiphenyl (4-ABP). 4-ABP undergoes metabolic activation to N-hydroxy-4-aminobiphenyl...

Topics

Aminobiphenyl Compounds
Animals
DNA Adducts
DNA Damage
Humans
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutagenesis
Mutagens
Mutation
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 33620775
DOI: 10.1002/em.22429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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