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Article

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.

Mutation research - 1 Mar 2015

Kucab Jill E, van Steeg Harry, Luijten Mirjam, Schmeiser Heinz H, White Paul A, Phillips David H, Arlt Volker M

Abstract excerpt

Somatic mutations in the tumour suppressor gene TP53 occur in more than 50% of human tumours; in some instances exposure to environmental carcinogens can be linked to characteristic mutational signatures. The Hupki (human TP53 knock-in) mouse embryo fibroblast (HUF) immortalization assay (HIMA) is a useful model for studying the impact of environmental carcinogens on TP53 mutagenesis. In an effort to increase the...

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Identifiers

PMID: 25847421
DOI: 10.1016/j.mrfmmm.2015.01.013
PMCID: PMC4547099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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