Article
TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.
Mutation research - 1 Mar 2015
Kucab Jill E, van Steeg Harry, Luijten Mirjam, Schmeiser Heinz H, White Paul A, Phillips David H, Arlt Volker M
Abstract excerpt
Somatic mutations in the tumour suppressor gene TP53 occur in more than 50% of human tumours; in some instances exposure to environmental carcinogens can be linked to characteristic mutational signatures. The Hupki (human TP53 knock-in) mouse embryo fibroblast (HUF) immortalization assay (HIMA) is a useful model for studying the impact of environmental carcinogens on TP53 mutagenesis. In an effort to increase the...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Animals
- Benzo(a)pyrene
- Cell Survival
- Cells, Cultured
- Codon
- DNA Adducts
- DNA Repair
- Fibroblasts
- Genes, p53
- Humans
- Mice
- Mutagens
- Mutation
- Oxygen