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Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model

1 Jun 2010

Abstract excerpt

TP53 is one of the most commonly mutated genes in human tumours. Variations in the types and frequencies of mutations at different tumour sites suggest that they may provide clues to the identity of the causative mutagenic agent. A useful model for studying human TP53 mutagenesis is the partial human TP53 knock-in (Hupki) mouse containing exons 4-9 of human TP53 in place of the corresponding mouse exons. For an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20553493
DOI: 10.1111/j.1742-464x.2010.07676.x

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