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TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database

1 Nov 2001

Abstract excerpt

A database of all published TP53 mutations in human cancer is maintained at the International Agency for Research on Cancer (IARC). In lung cancers, TP53 mutation patterns show an exceptionally high prevalence of G→T transversions, mostly occurring at codons demonstrated to be sites of adduction of metabolites of polycyclic aromatic hydrocarbons such as benzo[a]pyrene, one of the major carcinogens of tobacco...

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PMID: 11682648
DOI: 10.1093/mutage/16.6.551

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