Article
The genome as a record of environmental exposure.
Mutagenesis - 1 Nov 2015
Nik-Zainal Serena, Kucab Jill E, Morganella Sandro, Glodzik Dominik, Alexandrov Ludmil B, Arlt Volker M, Weninger Annette, Hollstein Monica, Stratton Michael R, Phillips David H
Abstract excerpt
Whole genome sequencing of human tumours has revealed distinct patterns of mutation that hint at the causative origins of cancer. Experimental investigations of the mutations and mutation spectra induced by environmental mutagens have traditionally focused on single genes. With the advent of faster cheaper sequencing platforms, it is now possible to assess mutation spectra in experimental models across the whole...
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