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Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53.

Carcinogenesis - 1 Oct 2005

Jaworski Maike, Hailfinger Stephan, Buchmann Albrecht, Hergenhahn Manfred, Hollstein Monica, Ittrich Carina, Schwarz Michael

Abstract excerpt

Mouse models are important tools in toxicologic research. Differences between species in pathways contributing to tumor development, however, raise the question in how far mouse models are valid for human risk assessment. One striking difference relates to the frequency of spontaneous liver cancer which is high in certain mouse strains but rather low in humans. Similarly, mutation frequencies in cancer genes are...

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PMID: 15917304
DOI: 10.1093/carcin/bgi142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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