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Article

MEF immortalization to investigate the ins and outs of mutagenesis.

Carcinogenesis - 1 Nov 2006

vom Brocke Jochen, Schmeiser Heinz H, Reinbold Manuela, Hollstein Monica

Abstract excerpt

The importance of tumor suppressor/oncogene mutations in tumor development is clear, but the causes of the DNA sequence changes in human cancers are not. Although elegant experiments with transgenic mice harboring lacZ or cII target sequences show that exposure to mutagenic human carcinogens can cause base substitutions in vivo, it does not follow from this that the mutations found in human cancers have to be the...

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PMID: 16777987
DOI: 10.1093/carcin/bgl101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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