Article
p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer.
Mutation research - 16 Jul 1999
Hussain S P, Harris C C
Abstract excerpt
The activation of protooncogenes and inactivation of tumor suppressor genes in affected cells are considered as the core events that provide a selective growth advantage and clonal expansion during the multistep process of carcinogenesis. Somatic mutations, induced by exogenous or endogenous mechanisms, were found to alter the normal functions of the p53 tumor suppressor gene. p53 is the most prominent example of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.