Article

Resolving the chromatin impact of mosaic variants with targeted Fiber-seq

2024-07-13

Abstract excerpt

Accurately quantifying the functional consequences of non-coding mosaic variants requires the pairing of DNA sequence with both accessible and closed chromatin architectures along individual DNA molecules—a pairing that cannot be achieved using traditional fragmentation-based chromatin assays. We demonstrate that targeted single-molecule chromatin fiber sequencing (Fiber-seq) achieves this, permitting single-molec...

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Literature Corpus work: c5d8b24f-1c6e-5140-879b-77d6b43c709a
DOI: 10.1101/2024.07.09.602608

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