Article

MOCHA: advanced statistical modeling of scATAC-seq data enables functional genomic inference in large human disease cohorts

2023-06-24

Abstract excerpt

Single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) has been increasingly used to study gene regulation. However, major analytical gaps limit its utility in studying gene regulatory programs in complex diseases. We developed MOCHA (Model-based single cell Open CHromatin Analysis) with major advances over existing analysis tools, including: 1) improved identification of sample-speci...

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Literature Corpus work: 29152ec3-71c6-5617-b873-324886d97c9a
DOI: 10.1101/2023.06.23.544827

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