Article

High-throughput screening of human genetic variants by pooled prime editing

2024-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the effects of rare genetic variants remains challenging, both in coding and non-coding regions. While multiplexed assays of variant effect (MAVEs) have enabled scalable functional assessment of variants, established MAVEs are limited by either exogenous expression of variants or constraints of genome editing. Here, we introduce a pooled prime editing (PE) platform in haploid human...

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Literature Corpus work: 44ac8fb7-69e9-59eb-b9a1-789fab62158a
DOI: 10.1101/2024.04.01.587366

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