Article

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespan

2022-07-13

Abstract excerpt

<h4>SUMMARY</h4> Systematic understanding of immune dynamics across the entire human lifespan at single-cell resolution is currently lacking. Here, we performed single-cell RNA sequencing (scRNA-seq) and single-cell T cell receptor (TCR)/B cell receptor (BCR) sequencing (scTCR/BCR-seq) on over 380,000 peripheral blood mononuclear cells collected from 45 healthy participants aged 0 to over 90 years. We revealed th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5cc3ebf-5f21-5170-94f0-e6efd119c8ad
DOI: 10.1101/2022.07.11.498621

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated single-cell sequencing analysis reveals peripheral immune landscape across the human lifespanDOI 10.1101/2022.07.11.498621Read

A human circulating immune cell landscape in aging and COVID-19Semantic proximity Read

Single-cell RNA sequencing reveals the molecular features of peripheral blood immune cells in children, adults and centenariansSemantic proximity Read

Longitudinal Multi-omic Immune Profiling Reveals Age-Related Immune Cell Dynamics in Healthy AdultsSemantic proximity Read

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signaturesSemantic proximity Read

Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescenceSemantic proximity Read

Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human ImmunosenescenceSemantic proximity Read

Longitudinal analysis reveals age-related changes in the T cell receptor repertoire of human T cell subsetsSemantic proximity Read

Deciphering Immunosenescence From Child to Frailty: Transcriptional Changes, Inflammation Dynamics, and Adaptive Immune AlterationsSemantic proximity Read

Sexual-dimorphism in human immune system agingSemantic proximity Read

Sex-specific trajectories of nonlinear immune aging at single cell levelSemantic proximity Read

Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevitySemantic proximity Read

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging processSemantic proximity Read