Article

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

2024-04-02

Abstract excerpt

The immune system undergoes progressive functional remodeling from neonatal stages to old age. Therefore, understanding how aging shapes immune cell function is vital for precise treatment of patients at different life stages. Here, we constructed the first transcriptomic atlas of immune cells encompassing human lifespan, ranging from newborns to supercentenarians, and comprehensively examined gene expression sign...

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Literature Corpus work: 2c60c835-726a-52ef-8376-ad4c2c3d7744
DOI: 10.1101/2024.04.01.587649

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