Article
Targeted chromosomal Escherichia coli:dnaB exterior surface residues regulate DNA helicase behavior to maintain genomic stability and organismal fitness.
PLoS genetics - 1 Nov 2021
Behrmann Megan S, Perera Himasha M, Hoang Joy M, Venkat Trisha A, Visser Bryan J, Bates David, Trakselis Michael A
Abstract excerpt
Helicase regulation involves modulation of unwinding speed to maintain coordination of DNA replication fork activities and is vital for replisome progression. Currently, mechanisms for helicase regulation that involve interactions with both DNA strands through a steric exclusion and wrapping (SEW) model and conformational shifts between dilated and constricted states have been examined in vitro. To better...
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