Article

Bacteria-to-human protein networks reveal origins of endogenous DNA damage

2018-06-26

Abstract excerpt

<h4>SUMMARY</h4> DNA damage provokes mutations and cancer, and results from external carcinogens or endogenous cellular processes. Yet, the intrinsic instigators of DNA damage are poorly understood. Here we identify proteins that promote endogenous DNA damage when overproduced: the DNA-damaging proteins (DDPs). We discover a large network of DDPs in Escherichia coli and deconvolute them into six DNA-damage-causi...

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Literature Corpus work: 70254b31-5537-5d04-9d91-6fe10fe5746b
DOI: 10.1101/354589

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