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Mutational signatures driven by epigenetic determinants stratify patients for therapeutic interventions in gastric cancer

2020-04-22

Abstract excerpt

DNA mismatch repair deficiency (dMMR) leads to increased mutation load, which in turn may impact anti-tumor immune responses and treatment effectiveness. Currently, there are different mutational signatures described in primary cancers that are associated with dMMR. Whether the somatic and epigenetic changes in MMR genes precede one or more dMMR signatures, and if so by which mechanism remains unknown. To investig...

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Literature Corpus work
c5bbc8e5-f0b1-508f-a441-ceef83b2c356
DOI
10.1101/2020.04.17.20066944
Open publication

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Mutational signatures driven by epigenetic determinants stratify patients for therapeutic interventions in gastric cancerDOI 10.1101/2020.04.17.20066944
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