Article
Acquisition Process and Clinical Relevance of dMMR-Associated Mutational Signatures in Hepatocellular Carcinoma.
Liver international : official journal of the International Association for the Study of the Liver - 1 Jul 2025
Ueno Masayuki, Takeda Haruhiko, Takai Atsushi, Nakano Shigeharu, Fujii Yosuke, Mishima Masako, Iguchi Eriko, Inuzuka Tadashi, Shimizu Takahiro, Jinnouchi Keita, Haga Hironori, Hatano Etsuro, Seno Hiroshi
Abstract excerpt
BACKGROUND AND AIMS: Multiple systemic therapies have received approval for hepatocellular carcinoma (HCC), necessitating the prediction of treatment efficacy to promote personalised treatment strategies. Mutational signatures reflect the mutational processes in human cancers and have emerged as promising biomarkers. In this study, we aimed to elucidate the acquisition process and clinical relevance of mismatch...
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