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Article

Sex differences in gastric cancer mutational burden reflect MLH1-associated epigenetic regulation.

BMC cancer - 15 Jun 2026

Klein Noa, Shweiki Dorit

Abstract excerpt

BACKGROUND: Tumor mutational burden (TMB) is widely used as a biomarker for predicting response to immune checkpoint inhibitors. Therefore, understanding its variability across patient groups, particularly between sexes, and its underlying biological determinants is of critical importance. METHODS: We analyzed autosomal TMB and its association with DNA repair-related regulatory mechanisms in gastric cancer across...

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Topics

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Share to Biomarkers, Tumor
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to MutL Protein Homolog 1

Share to Promoter Regions, Genetic

Share to Sex Factors

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42289660
DOI: 10.1186/s12885-026-16327-1
PMCID: PMC13501732

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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