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Mutations of PI3K-AKT-mTOR Pathway as Predictors for Immune Cell Infiltration and Immunotherapy Efficacy in dMMR/MSI-H Gastric Adenocarcinoma

2021-10-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely unknown. We sought to investigate the genomic correlates of the density of tumor-infiltrating immune cells (DTICs) and primary resistance...

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Literature Corpus work
a6c97fdd-0564-5456-be14-0e19dc936ce2
DOI
10.21203/rs.3.rs-929879/v1
Open publication

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Mutations of PI3K-AKT-mTOR Pathway as Predictors for Immune Cell Infiltration and Immunotherapy Efficacy in dMMR/MSI-H Gastric AdenocarcinomaDOI 10.21203/rs.3.rs-929879/v1
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