Identifying gastric cancer molecular subtypes by integrating DNA-based hierarchical classification strategy and clinical stratification

Abstract excerpt

<h4>Background</h4> Molecular subtyping has been introduced to better understand the genetic landscape of gastric cancer ( GC ), but current subtyping methods only had limited success because of the mixed use of molecular features, a lack of strategy optimization, and the limited availability of GC samples. The community urgently calls for a precise, and easily adoptable subtyping method to enable DNA-based earl...

Topics

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• Cancer Mechanisms and Therapy
• Cholangiocarcinoma and Gallbladder Cancer Studies
• Epigenesis, Genetic
• Gene Expression Regulation, Neoplastic
• Genomics
• High-Throughput Nucleotide Sequencing
• Mutation
• Stomach Neoplasms

Identifiers and source

Literature Corpus work

259c3735-c1de-5d77-a5cd-3388091886e7

DOI

10.1101/2023.06.09.544302