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Article

Mutations of PI3K-AKT-mTOR pathway as predictors for immune cell infiltration and immunotherapy efficacy in dMMR/MSI-H gastric adenocarcinoma.

BMC medicine - 21 Apr 2022

Wang Zhenghang, Wang Xinyu, Xu Yu, Li Jian, Zhang Xiaotian, Peng Zhi, Hu Yajie, Zhao Xinya, Dong Kun, Zhang Bei, Gao Chan, Zhao Xiaochen, Chen Hui, Cai Jinping, Bai Yuezong, Sun Yu, Shen Lin

Abstract excerpt

BACKGROUND: A significant subset of mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) gastric adenocarcinomas (GAC) are resistant to immune checkpoint inhibitors (ICIs), yet the underlying mechanism remains largely unknown. We sought to investigate the genomic correlates of the density of tumor-infiltrating immune cells (DTICs) and primary resistance to ICI treatment. METHODS: Four...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35443723
DOI: 10.1186/s12916-022-02327-y
PMCID: PMC9022268

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