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Article

Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jan 2015

Yoda Yukie, Takeshima Hideyuki, Niwa Tohru, Kim Jeong Goo, Ando Takayuki, Kushima Ryoji, Sugiyama Toshiro, Katai Hitoshi, Noshiro Hirokazu, Ushijima Toshikazu

Abstract excerpt

BACKGROUND: The profiles of genetic and epigenetic alterations in cancer-related pathways are considered to be useful for selection of patients likely to respond to specific drugs, including molecular-targeted and epigenetic drugs. In this study, we aimed to characterize such profiles in gastric cancers (GCs). METHODS: Genetic alterations of 55 cancer-related genes were analyzed by a benchtop next-generation...

Topics

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DNA Methylation
Epigenesis, Genetic
Gene Amplification
Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metabolic Networks and Pathways

Stomach Neoplasms

TOR Serine-Threonine Kinases

Wnt Signaling Pathway

Source

Identifiers

PMID: 24510342
DOI: 10.1007/s10120-014-0348-0

Genes

MLH1
CDH1
CHFR
CTNNB1
DKK3
ERBB2
FLT3
KRAS
NKD1
PTPN11
SFRP1

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