Article

Neuronal lineage tracing from progenitors in human cortical organoids reveals novel mechanisms of human neuronal production, diversity, and disease

2023-06-17

Abstract excerpt

The contribution of progenitor subtypes to generate the billions of neurons during human cortical neurogenesis is not well understood. We developed the Cortical ORganoid Lineage Tracing (COR-LT) system for human cortical organoids. Differential fluorescent reporter activation in distinct progenitor cells leads to permanent reporter expression, enabling the progenitor cell lineage of neurons to be determined. Surpr...

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Literature Corpus work: c5b8f3f9-4a21-50c4-89a6-b82bea7880e8
DOI: 10.1101/2023.06.17.545314

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