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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs).

Journal of visualized experiments : JoVE - 2 Mar 2018

Williams Madeline, Prem Smrithi, Zhou Xiaofeng, Matteson Paul, Yeung Percy Luk, Lu Chi-Wei, Pang Zhiping, Brzustowicz Linda, Millonig James H, Dicicco-Bloom Emanuel

Abstract excerpt

Human brain development proceeds through a series of precisely orchestrated processes, with earlier stages distinguished by proliferation, migration, and neurite outgrowth; and later stages characterized by axon/dendrite outgrowth and synapse formation. In neurodevelopmental disorders, often one or more of these processes are disrupted, leading to abnormalities in brain formation and function. With the advent of...

Topics

Animals
Cell Differentiation
Cell Movement
Humans
Mice
Neural Stem Cells
Neurodevelopmental Disorders
Neurons
Phenotype
Rats

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PMID: 29553565
DOI: 10.3791/56628
PMCID: PMC5931427

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