Article

Lineage recording reveals dynamics of cerebral organoid regionalization

2020-06-20

Abstract excerpt

Diverse regions develop within cerebral organoids generated from human induced pluripotent stem cells (iPSCs), however it has been a challenge to understand the lineage dynamics associated with brain regionalization. Here we establish an inducible lineage recording system that couples reporter barcodes, inducible CRISPR/Cas9 scarring, and single-cell transcriptomics to analyze lineage relationships during cerebral...

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Literature Corpus work: 671405a7-961f-581a-8152-807a2661ed0d
DOI: 10.1101/2020.06.19.162032

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