Article

Cohesin interacts with a panoply of splicing factors required for cell cycle progression and genomic organization

2018-05-17

Abstract excerpt

The cohesin complex regulates sister chromatid cohesion, chromosome organization, gene expression, and DNA repair. Here we report that endogenous human cohesin interacts with a panoply of splicing factors and RNA binding proteins, including diverse components of the U4/U6.U5 tri-snRNP complex and several splicing factors that are commonly mutated in cancer. The interactions are enhanced during mitosis, and the int...

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Literature Corpus work: c5b0b63d-a224-540c-993f-0354816a73dd
DOI: 10.1101/325209

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