Article
Functional impact of cancer-associated cohesin variants on gene expression and cellular identity.
Genetics - 15 Apr 2021
Rittenhouse Natalie L, Carico Zachary M, Liu Ying Frances, Stefan Holden C, Arruda Nicole L, Zhou Junjie, Dowen Jill M
Abstract excerpt
Cohesin is a ring-shaped protein complex that controls dynamic chromosome structure. Cohesin activity is important for a variety of biological processes, including formation of DNA loops that regulate gene expression. The precise mechanisms by which cohesin shapes local chromosome structure and gene expression are not fully understood. Recurrent mutations in cohesin complex members have been reported in various...
Topics
- Animals
- Cell Cycle Proteins
- Cell Differentiation
- Cell Line
- Chromosomal Proteins, Non-Histone
- Enhancer Elements, Genetic
- Gene Expression Regulation, Neoplastic
- Male
- Mice
- Mice, Inbred C57BL