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Article

Functional impact of cancer-associated cohesin variants on gene expression and cellular identity.

Genetics - 15 Apr 2021

Rittenhouse Natalie L, Carico Zachary M, Liu Ying Frances, Stefan Holden C, Arruda Nicole L, Zhou Junjie, Dowen Jill M

Abstract excerpt

Cohesin is a ring-shaped protein complex that controls dynamic chromosome structure. Cohesin activity is important for a variety of biological processes, including formation of DNA loops that regulate gene expression. The precise mechanisms by which cohesin shapes local chromosome structure and gene expression are not fully understood. Recurrent mutations in cohesin complex members have been reported in various...

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Source

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Identifiers

PMID: 33704438
DOI: 10.1093/genetics/iyab025
PMCID: PMC8049558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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