Article

Heterologous expression of the human cohesin complex in <i>Saccharomyces cerevisiae</i> results in a dominant-negative phenotype

2026-04-07

Abstract excerpt

<h4>ABSTRACT</h4> The cohesin complex has conserved roles in sister chromatid cohesion, DNA replication, genome organization, and the DNA damage response. We heterologously expressed the human cohesin complex in yeast to probe the behaviour of human cohesin. Human cohesin was unable to complement loss of function mutations in yeast cohesin, either as single subunits or as complexes, including in the context of co...

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Literature Corpus work: 27427db5-ba92-5cff-9345-566d99eb6432
DOI: 10.64898/2026.04.03.716359

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