Article

Notochord and axial progenitor generation by timely BMP and NODAL inhibition during vertebrate trunk formation

2023-02-28

Abstract excerpt

The formation of the vertebrate body involves the coordinated and progressive production of trunk tissues from progenitors located in the posterior of the embryo. In vitro models based on pluripotent stem cells (PSCs) replicate aspects of this process, but they lack some tissue components normally present in the trunk. Most strikingly, the notochord, a hallmark of chordates and the source of midline signals that p...

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Literature Corpus work: c5a6666a-f312-5ebb-a21f-b8b3ffd3e6b3
DOI: 10.1101/2023.02.27.530267

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