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Article

Putative oncogene Brachyury ( T ) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT

22 Mar 2016

Abstract excerpt

The transcription factor Brachyury (T) gene is expressed throughout primary mesoderm (primitive streak and notochord) during early embryonic development and has been strongly implicated in the genesis of chordoma, a sarcoma of notochord cell origin. Additionally, T expression has been found in and proposed to play a role in promoting epithelial-mesenchymal transition (EMT) in various other types of human tumors....

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PMID: 27006501
DOI: 10.1073/pnas.1601252113

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Putative oncogene Brachyury ( T ) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMTPMID 27006501Read ↗

In vivo knockdown of Brachyury results in skeletal defects and urorectal malformations resembling caudal regression syndrome.Semantic proximity Read ↗

Conserved enhancer logic controls the notochord expression of vertebrate <i>Brachyury</i>Semantic proximity Read ↗

Transcriptional Profiling Supports the Notochordal Origin of Chordoma and Its Dependence on a TGFB1-TBXT NetworkSemantic proximity Read ↗

Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survivalSemantic proximity Read ↗

Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice.Semantic proximity Read ↗

The Roles of Embryonic Transcription Factor BRACHYURY in Tumorigenesis and ProgressionSemantic proximity Read ↗

Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomasSemantic proximity Read ↗

Notochord and axial progenitor generation by timely BMP and NODAL inhibition during vertebrate trunk formationSemantic proximity Read ↗

no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene.Semantic proximity Read ↗

Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development.Semantic proximity Read ↗

Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular targetSemantic proximity Read ↗

Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation.Semantic proximity Read ↗

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